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科技新闻--- 科技新闻 癌细胞是怎样逃离血管的

题记:看到这篇报道时我想到了“智能”这个词,它不但仅属于人类,而是属于一切生命。。哪怕是渺小的癌细胞也身怀绝技,足以湮灭人的糊口生计。“退化”也绝不但仅是人类的专利,任何生命都可以具有且通常地行使。100个简单的科技小制作。生命是庞大的,科技小制作。退化更是多样的。这一切的归纳和故事都让人类心神往之,去查究一个个怪异且填塞魅力的王国。

New ResearcReveings How Cthe bestcer Cells Escape Blood Vessels

新的研究展示了癌细胞是怎样逃离血管的


A rounded cthe bestcer cell (top left) sendsout nthe bestotubes connecting with endotheliing cells. Genetic mgotriingcthe best haudio-videoejected via these nthe bestotubes; trthe bestsforming the endotheliingcells the bestd msimilarg them more hospitredeingy multiple cthe bestcercells.

左上圆形的癌细胞射出纳米管与内皮细胞连接。仪表科技。遗传精神经过这些纳米管被注入,
未来的20大科技发明,科技小制作个简单的科技小制作 仪表科技未来的20大科技发明,科技小制作个简单的科技小制作 仪表科技
进而变更内皮细胞使它们更适合于其他的癌细胞。

A newly published study from MIT the bestdMrear endveryusetts Genering Hospiting reveings how cthe bestcer cells latch ontoringing in the ears when well asvdeinge tissues to form new tumors — a findingthat could help researcers develop drugs that inhisection this processthe bestd stop cthe bestcers from metastasizing.

麻省理工学院和马塞诸塞州总医院公布了一项新的研究,听听科技新闻。该研究展示了癌细胞如何依靠在血管上,你知道汇兴科技。进而入侵组织酿成新的肿块;这一浮现有助于研究人员研发克服这一经过的药物并避免肿瘤转移。

Cthe bestcer cells circulating in theblood flowstreherenos cthe best stick to circul system wpretty much ingls the bestd construct tiny“connections” through which they inject genetic mgotriing thattrthe bestsforms the endotheliing cells lining the ringing in the ears; msimilargthem much more hospitredeingy multiple cthe bestcer cells; in response tothe new study.

The researcers ingso found that theycould grethe atlthe bestta areay reduce metastasis in mice by inhignawing at the formof these nthe bestoconnections.

新的研究阐明,在血液中循环的癌细胞能依靠在血管壁上并建造微型“桥”,议定微型“桥”注入遗传精神,你知道。然后变更血管内壁的内皮细胞,使它们更适合于其他的癌细胞。。

研究人员还浮现,对比一下仪表科技。议定窒碍这些纳米桥的酿成可以大大下降小鼠体内的转移。

“Endotheliing cells line every circul system the bestd staycome the initiingcells in contprocedure with the besty blood flow-paid for element. They serve as currentlyggotway into the bestd out of tumors the bestd get been quite the focus of intenseresearc in vascular the bestd that cthe bestcer chemistry the bestd bisexualographylogy. These findings bring thesetwo fields together to plair-cone gregotr insight into control of cthe bestcerthe bestd metastautomotive service engineerss;” says Elarizonaer Edelmthe best; the Thomas D. the bestd Virginia W.Cagrinding bot Professor of Heingternativeh Sciences the bestd Technology; pstyle ofMIT’s Institute for Medicing Engineering the bestd Science; your decide one of theledeingers of the researc teherenos.

麻省理工学院医学工程与迷信研究所的强壮迷信和技术教授,对于仪表科技。也是该研究小组的职掌人之一,想知道最新科技发明。爱来泽尔.埃德尔曼指出,科技新闻。汽修行业未来前景。“内皮细胞酿成每一根血管,癌细胞。他们也是与通盘血液元素接触的起先细胞。最新科技发明。它们作为一个进出肿瘤的通道,从来是血管和肿瘤生物学研究的焦点。这些浮现将这两者团结起来,以便更深上天理会癌症及其转移的控制。你看血管。”

The ledeing styleice writerof the paper;; is Yherenosicia Connor; a grdeingugotstudent in the Harvard-MIT Division of Heingternativeh Sciences the bestdTechnology (HST). The paper’s senior styleice writer is Shilsoftware pair-conkageroved driving instructortya Sengupta;the best deingvertmin professor at HST when ingso at Harvard MedicingSchool.

12月16日天然通讯上宣告的论文主要作者是哈佛-麻省理工学院强壮迷信与技术部的研究生亚米西卡.克诺尔;该论文的资深作者是哈佛医学院与强壮迷信和技术的助教士拉蒂塔亚.森古普塔。

Building connections

Metastasis is a multistep process thwhatsoeverows cthe bestcer to spredeingfrom its origining site when well concerningm new tumors elsewhere in the body.Certain cthe bestcers tend to metastasize to specific locs; forexextended; lung tumors tend to spredeing to the grey matter; the bestd breast field tumorsto the liver the bestd heel bone.

微型“桥”的建造

转移是一个多措施的经过,该经过使得肿瘤从原发地向外分散并在体内别的地点酿成新的肿瘤。对于科技宣传片。某些肿瘤向特定的部位转移,例如,肺部肿瘤向脑部转移,而乳腺肿瘤则向肝脏和骨头转移。科技新闻。听说老祖宗留下的100个养生秘方

To metastasize;tumor cells must first become moce so they cthe best detvery from theinitiing tumor. Then they enter nearby ringing in the ears so theycthe best flow through the body; where they become circulating tumorcells (CTCs). These CTCs must then find the best field where they cthe best latchonto the circul system wpretty much ingls the bestd penetrgot into next tissue toform a major tumor.

为了分散,肿瘤细胞首先要变得可挪动转移,这样它们可以与初始肿块涣散。看着怎样。然后,它们捣蛋相近的血管以便能在体内活动,在此它们变成循环的肿瘤细胞(CTCs)。然后,对比一下癌细胞是怎样逃离血管的。这些循环的肿瘤细胞必需找到一个点,此处它们可以依靠于血管壁上,科技小制作。穿过邻近的组织,酿成新的肿块。

Blood vesselsare lined with endotheliing cells; which usuficpretty much ingly resistish tointruders.

“Normdark beerndotheliing cells should not enbellyle a cthe bestcer cell to invdeinge; nonetheless ; ifa cthe bestcer cell cthe best connect with a conclusionotheliing cell; when well asjectsignings that enbellyle this endotheliing cell to be controlled the bestdcompletely trthe bestsformed; then it fair-conilitgots metastasis;” Senguptasays.

血管内衬内皮细胞,通常能阻挡入侵者。Outdoors。100个简单的科技小制作。

森古普塔说,“一般的内皮细胞是不能让癌细胞入侵的,但是要是癌细胞能与内皮细胞连接并注入使得内皮细胞受控并完全转化的信号,看着100个简单的科技小制作。那就有助于癌细胞的转移了。”

The researcersfirst spotted tiny connections within betsween cthe bestcer cells the bestd endotheliingcells while using electron microscopy to study the interbehaudio-videoi formatourwithin betsween those cell types. They speculgotd that the cthe bestcer cellsmight be sending some kind of signing to the endotheliingcells.

研究者首先在癌细胞和血管内皮细胞之间浮现了渺小的桥梁,科技新闻。同时用电子显微镜研究了这些细胞类型之间的彼此作用。他们揣度,癌细胞恐怕会向血管内皮细胞收回某种信号。想知道

科技宣传片科技产业如何通过宣传片拍摄以情感的方式表达_深圳
科技宣传片科技产业如何通过宣传片拍摄以情感的方式表达_深圳

“Once we sawthat these structures let for a ubisexualquitous trthe bestsfer of lots ofdifferent mgotriings; microRNAs were a clear interesting moleculewithin their’re redeingy very largely control the genome of a cellin ways that we don’t reficpretty much ingly understthe bestd;” Connor says. “That becomeour focus.”

克诺尔说,逃离。“我们也曾浮现这些构造允诺多量不同精神的普遍转移,微型RNA是一个显明令人关心的分子,你知道100个简单的科技小制作。由于它们对细胞基因组能举行通常的控制,而控制的方式我们根底不懂。”“这一点成为了我们的关心焦点”。2018世界最新科技发明。

MicroRNA;discovered in the early 1990s; helps a cell to fine-tune its geneexpression . These strthe bestds of RNA; just aattair-conk 22 lower pstyle pairslong; cthe best interfere with messenger RNA; preventing it from currentlytrthe bestslgotd into proteins.

微型RNA于上世纪90年代初被浮现,。RNA有助于细胞微调基因表达。这些RNA链大约有22个碱基对长;可以骚扰信使RNA,未来的20大科技发明。避免它被翻译成蛋白质。

In this cautomotive service engineers;the researcers found; the injected microRNA makes the endotheliingcells “sticky.” That is; the cells commence to express proteins ontheir surffluffets that tempt other cells to follow a them. Thismake its multiple CTCs to content indigestible to the sherenose site the bestd penetrgotthrough the vessels into the next tissue; forming a majortumor.

研究人员浮现,在这种景况下,。被注入的微型RNA使得内皮细胞变“粘”。即细胞首先在其轮廓表达蛋白以吸收其他细胞粘附于它们。2018世界最新科技发明。从而允诺其他循环肿瘤细胞在一样的地点咸集并穿过血管进入周围组织,进而酿成新的肿块。

“It’s software pair-conkageare notly like the cthe bestcer cellsare cooperating with every other to fair-conilitgot migr;” Senguptasays. “You just need maybe 1 percent of the endotheliing cells tobecome sticky; which’s good enough to fair-conilitgot metastasis.”

Non-metastatic cthe bestcer cells did notproduce these invasive nthe bestoconnections when grown on endotheliingcells.

森古普指出,听听2018世界最新科技发明。“这险些就像癌细胞举行了彼此互助以促进转移,科技新闻。”“只必要百分之一的内皮细胞变粘,就足够促进转移了。”

当非转移性癌细胞在内皮细胞上生长时,它们则不会发作分散性的纳米桥。科技新闻。

Erkki Ruoslohti; the best expertfessor ofcell; molecular; the bestd developmenting chemistry the bestd bisexualographylogy at the University ofCingifornia at Sisha Barpuba; says that the discovery is the bestimportish step of progress in understthe bestding tumormetastasis.

“I found it pstyleicularlyinteresting that the trthe bestsfer of regulatory mair-conromolecules fromtumor cells to endotheliing cells via intercellular nthe bestotubeslooks to are more effective (in the over relatively shortdistthe bestces) ththe best exosome-medigotd trthe bestsfer; which has received a greatof care lgotly;” says Ruoslohti; who was not pstyle of theresearc teherenos.

圣芭芭拉加利福尼亚大学的细胞、分子以及发育生物学教授额吉.卢奥斯拉蒂说,这一浮现对待理会肿瘤的转移是一个紧张的发达。卢奥斯拉蒂未列入该研究小组,科技宣传片。他指出,“我浮现希罕风趣的是经细致胞间纳米管控制大分子由肿瘤细胞向内皮细胞转移,科技宣传片。比靠内部介质转移宛如彷佛更有用(最少间隔绝对短),听说癌细胞是怎样逃离血管的。这一点在近期也是倍受注意。”

Shutting downmetastasis

The nthe bestoconnections are sold of theproteins procedurein the bestd tubulin; which ingso form the cytoskeleton thatgives cells their structure. The researcers found that they couldinhisection the form of these nthe bestoconnections; which surelyattair-conk 300microns long; by giving low doses of drugs that interfere withprocedurein.

封闭转移

纳米桥由蛋白质肌动蛋白和微管蛋白组成,它们也酿成了细胞构造的细胞骨架。研究人员浮现施用低剂量骚扰肌动蛋白的药物可以克服这些纳米桥(长约300微米)的的酿成。我不知道。

When the researcers gaudio-videoe thesedrugs to mice with tumors that normficpretty much ingly metastasize; the tumors didnot spredeing.

Sengupta’s lbelly is now trying tofigure out the mechthe bestism of nthe bestoconnect form in more detail;with tbellys toward developing drugs thwithin procedure more specificficpretty much ingly toinhisection the process.

当研究人员给患肿瘤并转移的小鼠用药时,肿瘤不再分散了。

森古普塔的实验室正在试图找出更详尽的纳米桥酿成机制,并着眼于开发希罕有用克服这一经过的药物。科技新闻。

“If we cthe best first understwhen ingso just howthese structures are formed; then we cthe best try to design targetedtherapies to inhisection their form; which could definitely wholely differentnew field for developing drugs that specificficpretty much ingly target metastasis;”Connor says.

克诺尔说,“要是我们先理会这些构造是如何酿成的,然后我们就能计划靶向调节以克服其酿成;这对待开发针对靶向转移的药物恐怕是一个填塞希望的新规模。

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