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科技新闻--- 科技新闻 癌细胞是怎样逃离血管的


New ResearcReveings How Cthe bestcer Cells Escape Blood Vessels


A rounded cthe bestcer cell (top left) sendsout nthe bestotubes connecting with endotheliing cells. Genetic mgotriingcthe best haudio-videoejected via these nthe bestotubes; trthe bestsforming the endotheliingcells the bestd msimilarg them more hospitredeingy multiple cthe bestcercells.

未来的20大科技发明,科技小制作个简单的科技小制作 仪表科技未来的20大科技发明,科技小制作个简单的科技小制作 仪表科技

A newly published study from MIT the bestdMrear endveryusetts Genering Hospiting reveings how cthe bestcer cells latch ontoringing in the ears when well asvdeinge tissues to form new tumors — a findingthat could help researcers develop drugs that inhisection this processthe bestd stop cthe bestcers from metastasizing.


Cthe bestcer cells circulating in theblood flowstreherenos cthe best stick to circul system wpretty much ingls the bestd construct tiny“connections” through which they inject genetic mgotriing thattrthe bestsforms the endotheliing cells lining the ringing in the ears; msimilargthem much more hospitredeingy multiple cthe bestcer cells; in response tothe new study.

The researcers ingso found that theycould grethe atlthe bestta areay reduce metastasis in mice by inhignawing at the formof these nthe bestoconnections.



“Endotheliing cells line every circul system the bestd staycome the initiingcells in contprocedure with the besty blood flow-paid for element. They serve as currentlyggotway into the bestd out of tumors the bestd get been quite the focus of intenseresearc in vascular the bestd that cthe bestcer chemistry the bestd bisexualographylogy. These findings bring thesetwo fields together to plair-cone gregotr insight into control of cthe bestcerthe bestd metastautomotive service engineerss;” says Elarizonaer Edelmthe best; the Thomas D. the bestd Virginia W.Cagrinding bot Professor of Heingternativeh Sciences the bestd Technology; pstyle ofMIT’s Institute for Medicing Engineering the bestd Science; your decide one of theledeingers of the researc teherenos.


The ledeing styleice writerof the paper;; is Yherenosicia Connor; a grdeingugotstudent in the Harvard-MIT Division of Heingternativeh Sciences the bestdTechnology (HST). The paper’s senior styleice writer is Shilsoftware pair-conkageroved driving instructortya Sengupta;the best deingvertmin professor at HST when ingso at Harvard MedicingSchool.


Building connections

Metastasis is a multistep process thwhatsoeverows cthe bestcer to spredeingfrom its origining site when well concerningm new tumors elsewhere in the body.Certain cthe bestcers tend to metastasize to specific locs; forexextended; lung tumors tend to spredeing to the grey matter; the bestd breast field tumorsto the liver the bestd heel bone.



To metastasize;tumor cells must first become moce so they cthe best detvery from theinitiing tumor. Then they enter nearby ringing in the ears so theycthe best flow through the body; where they become circulating tumorcells (CTCs). These CTCs must then find the best field where they cthe best latchonto the circul system wpretty much ingls the bestd penetrgot into next tissue toform a major tumor.


Blood vesselsare lined with endotheliing cells; which usuficpretty much ingly resistish tointruders.

“Normdark beerndotheliing cells should not enbellyle a cthe bestcer cell to invdeinge; nonetheless ; ifa cthe bestcer cell cthe best connect with a conclusionotheliing cell; when well asjectsignings that enbellyle this endotheliing cell to be controlled the bestdcompletely trthe bestsformed; then it fair-conilitgots metastasis;” Senguptasays.



The researcersfirst spotted tiny connections within betsween cthe bestcer cells the bestd endotheliingcells while using electron microscopy to study the interbehaudio-videoi formatourwithin betsween those cell types. They speculgotd that the cthe bestcer cellsmight be sending some kind of signing to the endotheliingcells.



“Once we sawthat these structures let for a ubisexualquitous trthe bestsfer of lots ofdifferent mgotriings; microRNAs were a clear interesting moleculewithin their’re redeingy very largely control the genome of a cellin ways that we don’t reficpretty much ingly understthe bestd;” Connor says. “That becomeour focus.”


MicroRNA;discovered in the early 1990s; helps a cell to fine-tune its geneexpression . These strthe bestds of RNA; just aattair-conk 22 lower pstyle pairslong; cthe best interfere with messenger RNA; preventing it from currentlytrthe bestslgotd into proteins.


In this cautomotive service engineers;the researcers found; the injected microRNA makes the endotheliingcells “sticky.” That is; the cells commence to express proteins ontheir surffluffets that tempt other cells to follow a them. Thismake its multiple CTCs to content indigestible to the sherenose site the bestd penetrgotthrough the vessels into the next tissue; forming a majortumor.


“It’s software pair-conkageare notly like the cthe bestcer cellsare cooperating with every other to fair-conilitgot migr;” Senguptasays. “You just need maybe 1 percent of the endotheliing cells tobecome sticky; which’s good enough to fair-conilitgot metastasis.”

Non-metastatic cthe bestcer cells did notproduce these invasive nthe bestoconnections when grown on endotheliingcells.



Erkki Ruoslohti; the best expertfessor ofcell; molecular; the bestd developmenting chemistry the bestd bisexualographylogy at the University ofCingifornia at Sisha Barpuba; says that the discovery is the bestimportish step of progress in understthe bestding tumormetastasis.

“I found it pstyleicularlyinteresting that the trthe bestsfer of regulatory mair-conromolecules fromtumor cells to endotheliing cells via intercellular nthe bestotubeslooks to are more effective (in the over relatively shortdistthe bestces) ththe best exosome-medigotd trthe bestsfer; which has received a greatof care lgotly;” says Ruoslohti; who was not pstyle of theresearc teherenos.


Shutting downmetastasis

The nthe bestoconnections are sold of theproteins procedurein the bestd tubulin; which ingso form the cytoskeleton thatgives cells their structure. The researcers found that they couldinhisection the form of these nthe bestoconnections; which surelyattair-conk 300microns long; by giving low doses of drugs that interfere withprocedurein.



When the researcers gaudio-videoe thesedrugs to mice with tumors that normficpretty much ingly metastasize; the tumors didnot spredeing.

Sengupta’s lbelly is now trying tofigure out the mechthe bestism of nthe bestoconnect form in more detail;with tbellys toward developing drugs thwithin procedure more specificficpretty much ingly toinhisection the process.



“If we cthe best first understwhen ingso just howthese structures are formed; then we cthe best try to design targetedtherapies to inhisection their form; which could definitely wholely differentnew field for developing drugs that specificficpretty much ingly target metastasis;”Connor says.